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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARAF All Species: 16.97
Human Site: S341 Identified Species: 31.11
UniProt: P10398 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10398 NP_001645.1 606 67585 S341 A V K V L K V S Q P T A E Q A
Chimpanzee Pan troglodytes XP_001155232 648 73032 V380 A V K I L K V V N P T P E Q F
Rhesus Macaque Macaca mulatta XP_001094928 606 67485 S341 A V K V L K V S Q P T A E Q A
Dog Lupus familis XP_548976 597 66626 A332 A V K V L K V A Q P T A E Q A
Cat Felis silvestris
Mouse Mus musculus P04627 604 67563 A339 A V K V L K V A Q P T A E Q A
Rat Rattus norvegicus P14056 604 67533 A339 A V K V L K V A Q P T A E Q A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516512 799 90020 T520 A V K M L N V T A P T P Q Q L
Chicken Gallus gallus P05625 647 73106 V380 A V K I L K V V D P T P E Q F
Frog Xenopus laevis P09560 638 71941 T371 A V K I L K V T D P T P E Q L
Zebra Danio Brachydanio rerio NP_991306 608 68644 T343 A I K I L K V T E P T P E Q L
Tiger Blowfish Takifugu rubipres NP_001033077 573 64648 S312 Q K R I G T G S F G T V F K G
Fruit Fly Dros. melanogaster P11346 782 88616 K503 A V K T L N V K T P S P A Q L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q07292 813 90389 V512 A I K K L N V V D P T P S Q M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.1 97 92.7 N.A. 95.2 95.5 N.A. 47.6 58.1 57.8 67.4 63.5 34.5 N.A. 32.8 N.A.
Protein Similarity: 100 70.8 97.6 94 N.A. 97 97 N.A. 57.7 71.2 70.6 77.8 74.2 48.8 N.A. 48 N.A.
P-Site Identity: 100 66.6 100 93.3 N.A. 93.3 93.3 N.A. 53.3 66.6 66.6 60 13.3 46.6 N.A. 46.6 N.A.
P-Site Similarity: 100 73.3 100 100 N.A. 100 100 N.A. 73.3 73.3 80 86.6 33.3 53.3 N.A. 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 93 0 0 0 0 0 0 24 8 0 0 39 8 0 39 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 8 0 0 0 70 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 16 % F
% Gly: 0 0 0 0 8 0 8 0 0 8 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 16 0 39 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 93 8 0 70 0 8 0 0 0 0 0 8 0 % K
% Leu: 0 0 0 0 93 0 0 0 0 0 0 0 0 0 31 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 0 24 0 0 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 93 0 54 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 39 0 0 0 8 93 0 % Q
% Arg: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 24 0 0 8 0 8 0 0 % S
% Thr: 0 0 0 8 0 8 0 24 8 0 93 0 0 0 0 % T
% Val: 0 77 0 39 0 0 93 24 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _